Cyclodextrin-bioadhesive nanoparticles for oral delivery of paclitaxel

Oral delivery is the most convenient and desired way for drug delivery. The major factor determinant for bioavailability of orally administered drug is the membrane permeability and drug solubility in the intestinal lumen. Many drugs show bioavailability problems due to their low water solubility, slow dissolution rate and instability in the gastrointestinal tract. One possibility to enhance drug absorption may be the use of biodegradable nanoparticulate systems with bioadhesive properties. Recently, Gantrez AN (PVM/MA) has been proposed as a new polymer to prepare bioadhesive nanoparticles for oral drug delivery (1). In the other hand, cyclodextrins (CDs) can improve drug solubility, and also increase the loading capacity of nanoparticles (2). Thus, the association between CDs and Gantrez nanoparticles would be a good strategy to increase the loading capacity of lipophilic drugs and modulate their release from these pharmaceutical forms. The objective of this study was to evaluate the feasibility of CD-Gantrez nanoparticles and their behaviour within the gut.